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Article

beta-Catenin is not required for proliferation and differentiation of epidermal mouse keratinocytes.

Journal of cell science - 1 Dec 2002

Posthaus Horst, Williamson Lina, Baumann Dominique, Kemler Rolf, Caldelari Reto, Suter Maja M, Schwarz Heinz, Müller Eliane

Abstract excerpt

Despite the pivotal role of beta-catenin in a variety of biological processes, conditional beta-catenin gene ablation in the skin of transgenic mice failed to affect interfollicular epidermal morphogenesis. We elucidated the molecular mechanisms underlying this phenomenon. Long-term cultures of homozygous, heterozygous and beta-catenin-null mutant keratinocytes were established to demonstrate that epidermal...

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Source

Identifiers

PMID: 12415003
DOI: 10.1242/jcs.00141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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