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Article

Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin.

Cell - 23 Feb 2001

Vasioukhin V, Bauer C, Degenstein L, Wise B, Fuchs E

Abstract excerpt

When surface epithelium was conditionally targeted for ablation of alpha-catenin, hair follicle development was blocked and epidermal morphogenesis was dramatically affected, with defects in adherens junction formation, intercellular adhesion, and epithelial polarity. Differentiation occurred, but epidermis displayed hyperproliferation, suprabasal mitoses, and multinucleated cells. In vitro, alpha-catenin null...

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Share to alpha Catenin
Share to Desmoplakins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Intercellular Junctions

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Share to Skin Physiological Phenomena

Source

Identifiers

PMID: 11239416
DOI: 10.1016/s0092-8674(01)00246-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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