Inactivation of Galpha(z) causes disassembly of the Golgi apparatus.

doi:10.1242/jcs.00093

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Article

Inactivation of Galpha(z) causes disassembly of the Golgi apparatus.

Journal of cell science - 1 Dec 2002

Nagahama Masami, Usui Shihomi, Shinohara Takashi, Yamaguchi Tomohiro, Tani Katsuko, Tagaya Mitsuo

Abstract excerpt

We showed previously that overexpression of the alpha subunit of G(z) or G(i2) suppresses nordihydroguaiaretic acid-induced Golgi disassembly. To determine whether the active form of Galpha is required to maintain the structure of the Golgi apparatus, we examined the effects of a series of Galpha GAPs, regulators of G protein signaling (RGS) proteins, on the Golgi structure. Expression of RGSZ1 or RGSZ2, both of...

Topics

Animals
Biological Transport, Active
Cell Line
Coatomer Protein
GTP-Binding Protein alpha Subunits
GTP-Binding Proteins
GTPase-Activating Proteins
Golgi Apparatus
HeLa Cells
Humans
Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mutagenesis, Site-Directed

Mutation

Nerve Tissue Proteins

Protein Binding

RGS Proteins

RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 12414994
DOI: 10.1242/jcs.00093

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12414994-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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