Article
Reactivation of ancestral strains of HIV-1 in the gp120 V3 env region in patients failing antiretroviral therapy and subjected to structured treatment interruption.
Virology - 10 Oct 2006
Silva Wilson Pereira, Santos Domingos E M, Leal Elcio, Brunstein Adriana, Sucupira Maria Cecilia A, Sabino Ester C, Diaz Ricardo Sobhie
Abstract excerpt
We analyzed gp120V3 HIV-1 env region genetic diversity of 27 patients failing antiretrovirals and subjected to 12-week structured treatment interruption (STI). Based on heteroduplex mobility assays, eight patients presented low pre- and post-STI genetic diversity (G1); five presented high pre-STI but low post-STI diversity (G2); five presented low pre-STI and high post-STI diversity (G3); and nine, high pre- and...
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