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Article

Apoptosis inhibitor as a suppressor of tumor progression: expression of Bcl-2 eliminates selective advantages for p53-deficient cells in the tumor.

Cancer biology & therapy - 1 Jan 2000

Gurova Katerina V, Kwek Serena S S, Koman Igor E, Komarov Andrei P, Kandel Eugene, Nikiforov Mikhail A, Gudkov Andrei V

Abstract excerpt

Inactivation of p53 and expression of Bcl-2, frequently occurring during tumor progression, have different prognostic value: while inactivation of p53 is generally associated with unfavorable prognosis, expression of Bcl-2 often correlates with better clinical outcome and delays selection of metastatic variants of experimental tumors. To analyze the mechanisms underlying the "anti-progression" function of Bcl-2,...

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Identifiers

PMID: 12170763
DOI: 10.4161/cbt.1.1.39

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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