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Article

Different patterns of bcl-6 and p53 gene mutations in tonsillar B cells indicate separate mutational mechanisms.

Molecular immunology - 1 Nov 2002

Yavuz Akif S, Monson Nancy L, Yavuz Sule, Grammer Amrie C, Longo Nancy, Girschick Hermann J, Lipsky Peter E

Abstract excerpt

Mutations within the 5'-non-coding region of the bcl-6 gene can occur in lymphomas that originate from germinal centers (GCs), as well as in normal memory and GC B cells. Mutations in the p53 gene occur in 50% of human cancers. Since both bcl-6 and p53 can be mutated in certain circumstances, we investigated the accumulation of mutations in these genes in individual tonsillar B and T cells to determine whether...

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PMID: 12413700
DOI: 10.1016/s0161-5890(02)00117-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Different patterns of bcl-6 and p53 gene mutations in tonsillar B cells indicate separate mutational mechanisms.PMID 12413700Read ↗

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