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Article

Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes.

Science (New York, N.Y.) - 12 Jun 1998

Shen H M, Peters A, Baron B, Zhu X, Storb U

Abstract excerpt

Immunoglobulin (Ig) genes are hypermutated in B lymphocytes that are the precursors to memory B cells. The mutations are linked to transcription initiation, but non-Ig promoters are permissible for the mutation process; thus, other genes expressed in mutating B cells may also be subject to somatic hypermutation. Significant mutations were not observed in c-MYC, S14, or alpha-fetoprotein (AFP) genes, but BCL-6 was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9624052
DOI: 10.1126/science.280.5370.1750

Genes

AFP
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes.PMID 9624052Read ↗

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