p53 mutations in Raji cells: characterization and localization relative to other Burkitt's lymphomas.

Abstract excerpt

The nuclear phosphoprotein p53 is an important regulator of cell proliferation in normal cells. Interestingly, the gene encoding p53 has usually undergone mutations in a wide range of tumor types. Recent studies of the p53 gene in Burkitt's lymphomas have demonstrated that mutations are extremely common, and in fact it is rare that both alleles of the p53 gene in these tumors are not inactivated by mutation or...

Topics

• Alleles
• Amino Acid Sequence
• Base Sequence
• Burkitt Lymphoma
• Cell Line
• Genes, p53
• Humans
• Molecular Sequence Data
• Mutation