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PSEN1, PSEN2, and APP mutations in 404 Chinese pedigrees with familial Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jan 2020

Jia Longfei, Fu Yue, Shen Luxi, Zhang Heng, Zhu Min, Qiu Qiongqiong, Wang Qi, Yan Xin, Kong Chaojun, Hao Jing, Wei Cuibai, Tang Yi, Qin Wei, Li Ying, Wang Fen, Guo Dongmei, Zhou Aihong, Zuo Xiumei, Yu Yueyi, Li Dan, Zhao Lina, Jin Hongmei, Jia Jianping

Abstract excerpt

INTRODUCTION: The PSENs/APP mutation distribution in Chinese patients with familial Alzheimer's disease (FAD) remains unclear. We aimed to analyze the genetic features of Chinese FAD pedigrees with and without PSENs/APP mutations. METHODS: In total, 1330 patients with Alzheimer's disease (AD) or mild cognitive impairment in 404 pedigrees were enrolled from the Chinese Familial Alzheimer's Disease Network....

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PMID: 31914229
DOI: 10.1002/alz.12005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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