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Article

The Role of Complement in the Development of Systemic Lupus Erythematosus

19 Mar 2004

Abstract excerpt

Complement has both beneficial and deleterious roles in the pathogenesis of systemic lupus erythematosus (SLE). On the one hand, patients with SLE present with decreased complement levels and with complement deposition in inflamed tissues, suggestive of a harmful role of complement in the effector phase of disease. On the other hand, homozygous deficiency of any of the classical pathway proteins is strongly...

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PMID: 15032584
DOI: 10.1146/annurev.immunol.22.012703.104549

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