Article
Complement deficiency and autoimmunity.
Current opinion in pediatrics - 1 Dec 1998
Sullivan K E
Abstract excerpt
Complete deficiency of one of the early components (C1, C4, or C2) of the classical pathway of the complement cascade is one of the strongest genetic risk factors for systemic lupus erythematosus that has been recognized. The lupus that occurs in complement-deficient individuals typically presents in early childhood. The association of complement deficiency and lupus has been known for over two decades, yet the...
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