Article
Critical role of the N-terminal residues of listeriolysin O in phagosomal escape and virulence of Listeria monocytogenes.
Molecular microbiology - 1 Oct 2002
Lety Marie-Annick, Frehel Claude, Berche Patrick, Charbit Alain
Abstract excerpt
A putative PEST sequence was recently identified close to the N-terminus of listeriolysin O (LLO), a major virulence factor secreted by the pathogenic Listeria monocytogenes. The deletion of this motif did not affect the secretion and haemolytic activity of LLO, but abolished bacterial virulence. Here, we first tested whether the replacement of the PEST motif of LLO by two different sequences, with either a very...
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