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Article

Differential Interactions Between Beclin 1 and Bcl-2 Family Members

26 Nov 2007

Abstract excerpt

Autophagy, a cellular degradation system, promotes both cell death and survival. The interaction between Bcl-2 family proteins and Beclin 1, a Bcl-2 interacting protein that promotes autophagy, can mediate crosstalk between autophagy and apoptosis. We investigated the interaction between anti-and pro-apoptotic Bcl-2 proteins with Beclin 1. Our results show that Beclin 1 directly interacts with Bcl-2, Bcl-x(L),...

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PMID: 17643073
DOI: 10.4161/auto.4713

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