Article
Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1.
The EMBO journal - 16 May 2007
Maiuri M Chiara, Le Toumelin Gaëtane, Criollo Alfredo, Rain Jean-Christophe, Gautier Fabien, Juin Philippe, Tasdemir Ezgi, Pierron Gérard, Troulinaki Kostoula, Tavernarakis Nektarios, Hickman John A, Geneste Olivier, Kroemer Guido
Abstract excerpt
The anti-apoptotic proteins Bcl-2 and Bcl-X(L) bind and inhibit Beclin-1, an essential mediator of autophagy. Here, we demonstrate that this interaction involves a BH3 domain within Beclin-1 (residues 114-123). The physical interaction between Beclin-1 and Bcl-X(L) is lost when the BH3 domain of Beclin-1 or the BH3 receptor domain of Bcl-X(L) is mutated. Mutation of the BH3 domain of Beclin-1 or of the BH3...
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