Article
Null mutation in human ciliary neurotrophic factor gene confers higher body mass index in males.
European journal of human genetics : EJHG - 1 Nov 2002
O'Dell Sandra D, Syddall Holly E, Sayer Avan Aihie, Cooper Cyrus, Fall Caroline H D, Dennison Elaine M, Phillips David I W, Gaunt Tom R, Briggs Patricia J, Day Ian N M
Abstract excerpt
Ciliary neurotrophic factor (CNTF) administration reduces weight in leptin-resistant mice via the signalling pathway normally activated by leptin. A G>A null mutation in the CNTF gene results in complete absence of protein. We hypothesised that absence of CNTF could lead to diminished initiation of anorectic pathways, with consequent increase in body mass. In 575 Caucasian men aged 59-73 years, the A/A genotype...
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