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Article

Sex-specific effects of CNTF, IL6 and UCP2 polymorphisms on weight gain.

Physiology & behavior - 12 Jan 2010

Heidema A Geert, Wang Ping, van Rossum Caroline T M, Feskens Edith J M, Boer Jolanda M A, Bouwman Freek G, Van't Veer Pieter, Mariman Edwin C M

Abstract excerpt

The human proteins ciliary neurotrophic factor (CNTF) and interleukin-6 (IL6) and their receptors share structural homology with leptin and its receptor. In addition, uncoupling protein-2 (UCP2) has been shown to participate the regulation of leptin on food intake. All three proteins are active in the hypothalamus. Experiments have shown that CNTF and IL6, like leptin, can influence body weight in humans and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19833146
DOI: 10.1016/j.physbeh.2009.10.002

Genes

CNTF
UCP2

Variants

rs1800169

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sex-specific effects of CNTF, IL6 and UCP2 polymorphisms on weight gain.PMID 19833146Read ↗

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