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Article

Ciliary neurotrophic factor null allele frequencies in schizophrenia, affective disorders, and Alzheimer's disease.

American journal of medical genetics - 19 Sept 1997

Gelernter J, Van Dyck C, van Kammen D P, Malison R, Price L H, Cubells J F, Berman R, Charney D S, Heninger G

Abstract excerpt

Ciliary neurotrophic factor (CNTF) is a cytokine that has been reported to affect cellular differentiation. Mouse CNTF knockouts have progressive motor neuron atrophy, but this protein has uncertain physiological function in humans. A naturally occurring CNTF variant in man, observed in many populations, abolishes function of the protein product, providing the opportunity to study loss of CNTF function in humans....

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Identifiers

PMID: 9342199

Genes

CNTF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ciliary neurotrophic factor null allele frequencies in schizophrenia, affective disorders, and Alzheimer's disease.PMID 9342199Read ↗

A null mutation in the human CNTF gene is not causally related to neurological diseases.Semantic proximity Read ↗

Association between a null mutation in the human ciliary neurotrophic factor (CNTF) gene and increased incidence of psychiatric diseases?Semantic proximity Read ↗

A null mutation allele in the CNTF gene and schizophrenic psychoses.Semantic proximity Read ↗

Schizophrenia and the ciliary neurotrophic factor (CNTF) gene: no evidence for association.Semantic proximity Read ↗

Ciliary neurotrophic factor null mutation and schizophrenia in a Swedish population.Semantic proximity Read ↗

Schizophrenic psychoses and the CNTF null mutation.Semantic proximity Read ↗

No association between the CNTF null mutation and schizophrenia or personality.Semantic proximity Read ↗

Ciliary neurotrophic factor null alleles are not a risk factor for Charcot-Marie-Tooth disease, hereditary neuropathy with pressure palsies and amyotrophic lateral sclerosis.Semantic proximity Read ↗

[Deficiency of human ciliary neurotropic factor (CNTF) is not causally related to amyotrophic lateral sclerosis (ALS)].Semantic proximity Read ↗

Investigation of a null mutation of the CNTF gene in familial amyotrophic lateral sclerosis.Semantic proximity Read ↗

Ciliary neurotrophic factor genotype does not influence clinical phenotype in amyotrophic lateral sclerosis.Semantic proximity Read ↗

Variants in neurotrophic factor genes and schizophrenic psychoses: no associations in a Spanish population.Semantic proximity Read ↗

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