Article
Selective targeting of point-mutated KRAS through artificial microRNAs.
Proceedings of the National Academy of Sciences of the United States of America - 23 May 2017
Acunzo Mario, Romano Giulia, Nigita Giovanni, Veneziano Dario, Fattore Luigi, Laganà Alessandro, Zanesi Nicola, Fadda Paolo, Fassan Matteo, Rizzotto Lara, Kladney Raleigh, Coppola Vincenzo, Croce Carlo M
Abstract excerpt
Mutated protein-coding genes drive the molecular pathogenesis of many diseases, including cancer. Specifically, mutated KRAS is a documented driver for malignant transformation, occurring early during the pathogenesis of cancers such as lung and pancreatic adenocarcinomas. Therapeutically, the indiscriminate targeting of wild-type and point-mutated transcripts represents an important limitation. Here, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.