Small molecules that reactivate mutant p53.

Abstract excerpt

Around half of all human tumours carry mutant p53. This allows escape from p53-induced cell cycle arrest and apoptosis. Many tumours express mutant p53 proteins at elevated levels. Restoration of wild-type p53 function should trigger massive apoptosis in tumour cells and thus eradicate tumours. Various types of small molecules have been identified that can restore native conformation and wild-type function to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antineoplastic Agents, Phytogenic
• Share to Apoptosis
• Share to Aza Compounds