Article
Association of interleukin-18 gene promoter polymorphisms in type 1 diabetes and autoimmune thyroid disease.
Annals of the New York Academy of Sciences - 1 Nov 2003
Ide Akane, Kawasaki Eiji, Abiru Norio, Sun Fuyan, Fukushima Tetsuya, Ishii Reiko, Takahashi Ryoko, Kuwahara Hironaga, Fujita Naruhiro, Kita Atsushi, Imaizumi Misa, Oshima Katsuya, Usa Toshiro, Uotani Shigeo, Ejima Eri, Yamasaki Hironori, Ashizawa Kiyoto, Yamaguchi Yoshihiko, Eguchi Katsumi
Abstract excerpt
Type 1 diabetes is a heterogeneous autoimmune disease and is often associated with other organ-specific autoimmune diseases, including autoimmune thyroid disease (AITD). IL-18 is a potent proinflammatory cytokine capable of inducing IFN-gamma production that is associated with the development of type 1 diabetes and AITD. The gene for IL-18 is located near Idd2 and has been reported to be associated with a...
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