Article
The -137G/C polymorphism of interleukin 18 promoter and risk of HIV-1 infection and its progression to AIDS.
Acta virologica - 1 Jan 2011
Sobti R C, Sharma V L, Abitew A M, Berhane N, Mahdi S A, Askari M, Kuttiat V S, Wanchu A
Abstract excerpt
A growing body of evidence suggests that host genetic factors play an important role both in susceptibility to human immunodeficiency virus 1 (HIV-1) infection and in progression to AIDS. Interleukin 18 (IL-18) is a pleiotropic proinflammatory cytokine that serves as an important regulator of immune responses. It plays a key role in induction of both Th1 and Th2 cytokines and, thereby, modulates their immune...
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