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Genetics in Autoimmune Hepatitis

1 Jan 2002

Abstract excerpt

Current hypotheses suggest that autoimmune hepatitis (AIH) is triggered by an environmental factor in a genetically susceptible host. Multiple genes may interact to produce a "permissive gene pool" that determines both disease risk and phenotype. Studies of type 1 AIH have focused on the major histocompatibility complex (MHC), mapping susceptibility to the DRB1 region. Three different molecular models have been...

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PMID: 12447707
DOI: 10.1055/s-2002-35705

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