Article
Genetic susceptibilities for immune expression and liver cell injury in autoimmune hepatitis.
Immunological reviews - 1 Apr 2000
Czaja A J, Donaldson P T
Abstract excerpt
Genetic susceptibility to type 1 autoimmune hepatitis in white northern Europeans is related to female sex, HLA alleles encoding the six amino acid sequence LLEQKR at positions 67-72 of the DRB1 polypeptide, and CTLA-4 gene polymorphism. The principal HLA alleles associated with type 1 autoimmune hepatitis in Britain and North America are DRB1*0301 and DRB1*0401. In this model of susceptibility, lysine at...
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