Article
Differential binding of pyruvate dehydrogenase complex-E2 epitopes by DRB1*08:01 and DRB1*11:01 Is predicted by their structural motifs and correlates with disease risk.
Journal of immunology (Baltimore, Md. : 1950) - 1 May 2013
Chow I-Ting, James Eddie A, Gates Theresa J, Tan Venus, Moustakas Antonis K, Papadopoulos George K, Kwok William W
Abstract excerpt
DRB1*08:01 (DR0801) and DRB1*11:01 (DR1101) are highly homologous alleles that have opposing effects on susceptibility to primary biliary cirrhosis (PBC). DR0801 confers risk and shares a key feature with other HLA class II alleles that predispose to autoimmunity: a nonaspartic acid at beta57. DR1101 is associated with protection from PBC, and its sequence includes an aspartic acid at beta57. To elucidate a...
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