Article
Oral efficacy of the new immunomodulator FTY720 in cynomolgus monkey kidney allotransplantation, given alone or in combination with cyclosporine or RAD.
Transplantation - 15 Oct 2002
Schuurman Henk-Jan, Menninger Klaus, Audet Maxime, Kunkler Adrien, Maurer Claudine, Vedrine Corinne, Bernhard Mario, Gaschen Lorrie, Brinkmann Volker, Quesniaux Valerie
Abstract excerpt
BACKGROUND: FTY720 is a novel immunomodulator with a unique mechanism of action, i.e. chemokine-dependent lymphocyte homing into secondary lymphoid organs associated with profound lymphocyte depletion in blood. We investigated its efficacy, either FTY720 alone or together with cyclosporine or the rapamycin derivative rapamycin derivative (RAD), in cynomolgus monkey kidney allotransplantation. METHODS:...
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