Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel anticytomegalovirus activity of immunosuppressant mizoribine and its synergism with ganciclovir.

The Journal of pharmacology and experimental therapeutics - 1 Jun 2010

Kuramoto Takashi, Daikoku Tohru, Yoshida Yoshihiro, Takemoto Masaya, Oshima Kumi, Eizuru Yoshito, Kanda Yoshinobu, Miyawaki Toshio, Shiraki Kimiyasu

Abstract excerpt

Cytomegalovirus (CMV) infection is a prominent infection in transplant recipients. The immunosuppressive drug mizoribine was shown to have anti-CMV activity in vitro and was reported to have an anti-CMV effect in renal transplantation. This study characterized the anti-CMV activity of mizoribine in vitro and its synergistic activity with ganciclovir. Mizoribine suppressed replication and at the EC(50) for plaque...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Synergism

Share to Ganciclovir

Share to Guanine

Share to Guanosine

Share to Immunosuppressive Agents

Share to Viral Plaque Assay

Source

Identifiers

PMID: 20194528
DOI: 10.1124/jpet.109.160630

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel anticytomegalovirus activity of immunosuppressant mizoribine and its synergism with ganciclovir.PMID 20194528Read ↗

Letermovir for Cytomegalovirus Prophylaxis in Hematopoietic-Cell TransplantationSemantic proximity Read ↗

Maribavir use in practice for cytomegalovirus infection in French transplantation centers.Semantic proximity Read ↗

Effect of Cell Culture Conditions on the Anticytomegalovirus Activity of MaribavirSemantic proximity Read ↗

Letermovir Prophylaxis for Cytomegalovirus in Hematopoietic-Cell TransplantationSemantic proximity Read ↗

Givinostat and hydroxyurea synergize in vitro to induce apoptosis of cells from JAK2(V617F) myeloproliferative neoplasm patients.Semantic proximity Read ↗

Virologic characterization of multidrug-resistant cytomegalovirus infection in 2 transplant recipients treated with maribavir.Semantic proximity Read ↗

Successful Treatment of UL97 Mutation Ganciclovir-Resistant Cytomegalovirus Viremia in a Renal Transplant Recipient With Letermovir and Adjunct Hyperimmune Cytomegalovirus Immunoglobulin: A Case Report.Semantic proximity Read ↗

Successful Treatment with Letermovir in a Heart Transplant Recipient with UL97 Mutation Ganciclovir-Resistant Cytomegalovirus Colitis and Viremia.Semantic proximity Read ↗

Differential cytotoxic effects of mizoribine and its aglycone on human and murine cells and on normal and enzyme-deficient human cells.Semantic proximity Read ↗

Maribavir Inhibits Epstein-Barr Virus Transcription in Addition to Viral DNA ReplicationSemantic proximity Read ↗

<i>OFF</i> -Target Effects of Mycophenolic Acid on BK Polyomavirus Replication in Primary Human Renal Proximal Tubular Epithelial CellsSemantic proximity Read ↗

Acyclovir: A Decade LaterSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.