Article
Belatacept and sirolimus prolong nonhuman primate renal allograft survival without a requirement for memory T cell depletion.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Feb 2013
Lo D J, Anderson D J, Weaver T A, Leopardi F, Song M, Farris A B, Strobert E A, Jenkins J, Turgeon N A, Mehta A K, Larsen C P, Kirk A D
Abstract excerpt
Belatacept is an inhibitor of CD28/B7 costimulation that is clinically indicated as a calcineurin inhibitor (CNI) alternative in combination with mycophenolate mofetil and steroids after renal transplantation. We sought to develop a clinically translatable, nonlymphocyte depleting, belatacept-based regimen that could obviate the need for both CNIs and steroids. Thus, based on murine data showing synergy between...
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