Article
Evidence of Viral Replication in Circulating Dendritic Cells during Hepatitis C Virus Infection
15 Jun 2003
Abstract excerpt
The existence of extrahepatic sites of hepatitis C virus (HCV) replication has been proposed as a mechanism responsible for the poor antiviral immune response found in chronic infection. Dendritic cells (DCs), as unique antigen-presenting cells able to induce a primary immune response, are prime targets of persistent viruses. From 24 blood samples obtained from HCV-seropositive patients, peripheral blood DCs...