Article
T cell receptor cross-recognition of an HIV-1 CD8+ T cell epitope presented by closely related alleles from the HLA-A3 superfamily.
International immunology - 1 Jul 2006
Lichterfeld Mathias, Williams Katie L, Mui Stanley K, Shah Shivani S, Mothe Bianca R, Sette Alessandro, Kim Arthur, Johnston Mary N, Burgett Nicole, Frahm Nicole, Cohen Daniel, Brander Christian, Rosenberg Eric S, Walker Bruce D, Altfeld Marcus, Yu Xu G
Abstract excerpt
HLA-A3 and -A11 share similar peptide-binding motifs, however, it is unclear if promiscuous epitope presentation by HLA-A3 or HLA-A11 is associated with promiscuous TCR recognition. Here, we show that despite widespread cross-presentation of identical HIV-1 peptides in HIV-1-infected individuals expressing HLA-A3 or HLA-A11, peptides presented by HLA-A3 or HLA-A11 commonly exhibited clear immune distinctiveness...
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