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Article

Involvement of IGF-1R regulation by miR-515-5p modifies breast cancer risk among BRCA1 carriers.

Breast cancer research and treatment - 1 Apr 2013

Gilam Avital, Edry Liat, Mamluk-Morag Efrat, Bar-Ilan Dalia, Avivi Camila, Golan David, Laitman Yael, Barshack Iris, Friedman Eitan, Shomron Noam

Abstract excerpt

Several lines of evidence indicate that sequence alterations within microRNA (miRNA)-binding sites can modify the binding to its target gene resulting in altered expression patterns. We hypothesized that a single nucleotide polymorphism (SNP) located in the miR-515-5p binding site of igf-1r gene may alter IGF-1R regulation, with consequent effects on breast cancer risk in BRCA1 mutation carriers. Computational...

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PMID: 23549953
DOI: 10.1007/s10549-013-2502-5

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BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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