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Article

Murine leukemia virus nucleocapsid mutant particles lacking viral RNA encapsidate ribosomes.

Journal of virology - 1 Nov 2002

Muriaux Delphine, Mirro Jane, Nagashima Kunio, Harvin Demetria, Rein Alan

Abstract excerpt

A single retroviral protein, termed Gag, is sufficient for assembly of retrovirus-like particles in mammalian cells. Gag normally selects the genomic RNA of the virus with high specificity; the nucleocapsid (NC) domain of Gag plays a crucial role in this selection process. However, encapsidation of the viral RNA is completely unnecessary for particle assembly. We previously showed that mutant murine leukemia...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12388701
DOI: 10.1128/jvi.76.22.11405-11413.2002
PMCID: PMC136761

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Source receipt: pubmed, retrieved 7 Sept 2026.

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