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Article

Nucleocapsid protein effects on the specificity of retrovirus RNA encapsidation

1 Sept 1995

Abstract excerpt

We have analyzed the roles of Gag protein nucleocapsid (NC) domains in the packaging or encapsidation of retroviral RNAs into virus particles. We found that mutation of both zinc finger motifs of the human immunodeficiency virus (HIV) NC domain reduced but did not eliminate encapsidation of the HIV viral RNA. However, the NC mutations also resulted in a three- to fourfold reduction in the specificity of RNA...

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PMID: 7637017
DOI: 10.1128/jvi.69.9.5716-5722.1995

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