Article
Non-cleavable mutant Fas ligand transfection of donor cornea abrogates ocular immune privilege.
Experimental eye research - 1 Oct 2002
Sano Yoichiro, Yamada Jun, Ishino Yutaka, Adachi Wakako, Kawasaki Satoshi, Suzuki Tomo, Kinoshita Shigeru, Okuyama Torayuki, Azuma Noriyuki
Abstract excerpt
The expression of Fas ligand (FasL) in donor corneal tissue has been thought to contribute to the prolonged survival of orthotopic corneal allografts. However, in solid organ transplantation, FasL gene-transfected tissues have been reported to lead to graft destruction through neutrophil recruitment. We wished to examine whether transfection of mutant FasL cDNA, which produces only membrane-binding forms of FasL...
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