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Article

Treatment of donor corneal tissue with immunomodulatory cytokines: a novel strategy to promote graft survival in high-risk corneal transplantation.

Scientific reports - 20 Apr 2017

Tahvildari Maryam, Emami-Naeini Parisa, Omoto Masahiro, Mashaghi Alireza, Chauhan Sunil K, Dana Reza

Abstract excerpt

Antigen-presenting cells (APCs) play an important role in transplant rejection and tolerance. In high-risk corneal transplantation, where the graft bed is inflamed and vascularized, immature APCs in the donor corneal stroma quickly mature and migrate to lymphoid tissues to sensitize host T cells. In this study, using a mouse model of corneal transplantation, we investigated whether enrichment of tolerogenic APCs...

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Identifiers

PMID: 28428556
DOI: 10.1038/s41598-017-01065-z
PMCID: PMC5430534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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