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TRANSFERRIN RECEPTOR-MEDIATED GENE TRANSFER TO THE CORNEAL ENDOTHELIUM1

1 Feb 2001

Abstract excerpt

BACKGROUND: The application of gene therapy to prevent allograft rejection requires the development of noninflammatory vectors. We have therefore investigated the use of a nonviral system, transferrin-mediated lipofection, to transfer genes into the cornea with the aim of preventing corneal graft rejection. METHODS: Rabbit and human corneas were cultured ex vivo and transfected with either lipofection alone or in...

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PMID: 11258435
DOI: 10.1097/00007890-200102270-00011

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