THE PRESENCE OF ACTIVATED DONOR HLA CLASS I-REACTIVE T LYMPHOCYTES IS ASSOCIATED WITH REJECTION OF CORNEAL GRAFTS

Abstract excerpt

Although the cornea is considered to be an immunological privileged site, corneal transplantation can result in immunological rejection followed by graft failure, especially in patients with vascularized corneas. Several studies suggest a beneficial effect of matching for the HLA class I antigens on corneal graft survival, although a large study (the Collaborative Corneal Transplantation Study) failed to confirm...

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