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Article

A new model of orthotopic penetrating corneal transplantation in the sheep: graft survival, phenotypes of graft-infiltrating cells and local cytokine production.

Australian and New Zealand journal of ophthalmology - 1 Apr 1999

Williams K A, Standfield S D, Mills R A, Takano T, Larkin D F, Krishnan R, Russ G R, Coster D J

Abstract excerpt

BACKGROUND: Orthotopic penetrating keratoplasty in the sheep was developed as an outbred preclinical model to allow correlation of the cellular infiltrate during graft rejection with local production of cytokine mRNA. METHODS: Penetrating corneal autografts and allografts were performed in Merino sheep. Graft outcome was followed at the slit-lamp. Corneal infiltrates were examined by immunoperoxidase staining on...

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Source

Identifiers

PMID: 10379711
DOI: 10.1046/j.1440-1606.1999.00171.x

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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