Article
Mice with mutations in Fas and Fas ligand demonstrate increased herpetic stromal keratitis following corneal infection with HSV-1.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2012
Morris Jessica E, Zobell Stephanie, Yin Xiao-Tang, Zakeri Hamideh, Summers Bretton C, Leib David A, Stuart Patrick M
Abstract excerpt
HSV-1 infection of the cornea leads to a potentially blinding immunoinflammatory lesion of the cornea, termed herpetic stromal keratitis. It has also been shown that one of the factors limiting inflammation of the cornea is the presence of Fas ligand (FasL) on corneal epithelium and endothelium. In this study, the role played by FasL expression in the cornea following acute infection with HSV-1 was determined....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.