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Article

New mutations in pncA of in vitro selected pyrazinamide-resistant strains of Mycobacterium tuberculosis.

Microbial drug resistance (Larchmont, N.Y.) - 1 Jan 2001

Bamaga M, Zhang H, Wright D J

Abstract excerpt

Mutations within the pncA gene can cause pyrazinamide (PZA) resistance in Mycobacterium tuberculosis. To study further the mutational events leading to PZA resistance, a H37Rv PZA-susceptible strain was used to derive PZA-resistant mutants in vitro. This parental strain was grown at gradually increased concentrations of PZA (from 200 up to 500 microg/ml). A total of eight variant strains were selected for further...

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PMID: 11759083
DOI: 10.1089/10766290152652765

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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