Article
Correlation of pncA sequence with pyrazinamide resistance level in BACTEC for 21 mycobacterium tuberculosis clinical isolates.
Microbial drug resistance (Larchmont, N.Y.) - 1 Jan 2000
Mestdagh M, Realini L, Fonteyne P A, Rossau R, Jannes G, Mijs W, DE Smet K A, Portaels F, Van den Eeckhout E
Abstract excerpt
Mutations in the pncA gene, encoding pyrazinamidase, are considered the major mechanism of pyrazinamide (PZA) resistance in Mycobacterium tuberculosis, but resistant strains containing the wild-type gene have been described. The correlation of pncA sequence with PZA resistance level was examined for 21 M. tuberculosis clinical isolates. Susceptibility patterns were determined for 100, 300, and 900 microg/ml...
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