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Article

Posttranscriptional compensation for heterozygous disruption of the kidney-specific NaK2Cl cotransporter gene.

Journal of the American Society of Nephrology : JASN - 1 Mar 2002

Takahashi Nobuyuki, Brooks Heddwen L, Wade James B, Liu Wen, Kondo Yoshiaki, Ito Sadayoshi, Knepper Mark A, Smithies Oliver

Abstract excerpt

Mice homozygous for a loss of function mutation of the kidney-specific NaK2Cl cotransporter, BSC1/NKCC2, do not survive. Here the effects of loss of one copy of the gene are studied. NKCC2 mRNA of NKCC2 +/- kidney was 55 +/- 6% of +/+, yet no differences were found between NKCC2 +/+ and +/- mice in BP, blood gas, electrolytes, creatinine, plasma renin concentration, urine volume and osmolality, ability to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Processing, Post-Translational

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Identifiers

PMID: 11856763
DOI: 10.1681/ASN.V133604

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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