Article
Lack of dependance of transcription-induced cytosine deaminations on protein synthesis.
Mutation research - 31 Oct 2002
Mokkapati Sanath Kumar, Bhagwat Ashok S
Abstract excerpt
Transcription-induced mutations (TIM) is a phenomenon in Escherichia coli in which transcription promotes C to T and other mutations in a strand-specific manner. Because the processes of transcription and translation are coupled in prokaryotes and some models regarding creating a hypermutagenic state in E. coli require new protein synthesis, we tested the possibility that TIM was dependent on efficient synthesis...
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