Article
Single-nucleotide polymorphisms in the class II region of the major histocompatibility complex in Japanese patients with immunoglobulin A nephropathy.
Journal of human genetics - 1 Jan 2002
Akiyama Fumihiro, Tanaka Toshihiro, Yamada Ryo, Ohnishi Yozo, Tsunoda Tatsuhiko, Maeda Shiro, Takei Takashi, Obara Wataru, Ito Kyoko, Honda Kazuho, Uchida Keiko, Tsuchiya Ken, Nitta Kosaku, Yumura Wako, Nihei Hiroshi, Ujiie Takashi, Nagane Yutaka, Miyano Satoru, Suzuki Yasushi, Fujioka Tomoaki, Narita Ichiei, Gejyo Fumitake, Nakamura Yusuke
Abstract excerpt
Immunoglobulin A nephropathy (IgAN) is a form of chronic glomerulonephritis of unknown etiology and pathogenesis. Immunogenetic studies have not conclusively indicated that human leukocyte antigen (HLA) is involved. As a first step in investigating a possible relationship between HLA class II genes and IgAN, we analyzed the extent of linkage disequilibrium (LD) in this region of chromosome 6p21.3 in a Japanese...
Topics
- Adult
- Alleles
- Case-Control Studies
- Chromosomes, Human, Pair 6
- Female
- Genes, MHC Class II
- Genetic Predisposition to Disease
- Genotype