Article
HLA-DQB1 and HLA-DRB1 expression is associated with disease severity in IgAN.
Annals of palliative medicine - 1 Sept 2021
Zhan Xueyu, Deng Fei, Wang Amanda Y, Chen Qin, Du Yongjing, Wang Qiuxia, Zhong Xiang, Zhang Ping, Wang Wei, Chen Shasha, Li Guisen, Wang Li, Wang Wei
Abstract excerpt
BACKGROUND: Several genome-wide association studies have found that HLA class II histocompatibility antigen, DQ beta1 (HLA-DQB1) and HLA class II histocompatibility antigen, DR beta1 (HLA-DRB1) were associated with immunoglobulin A nephropathy (IgAN). However, few studies have explored the association between HLA-DQB1 and HLA-DRB1 expression and IgAN. This is the first study to investigate the relationship...
Topics
- Alleles
- Gene Frequency
- Genome-Wide Association Study
- Glomerulonephritis, IGA
- HLA-DQ beta-Chains
- HLA-DRB1 Chains
- Haplotypes
- Humans
- Severity of Illness Index