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Article

Molecular characterization of thalassemia intermedia associated with HPFH-6/beta-thalassemia and HPFH-6/Hb E in Thai patients.

Acta haematologica - 1 Jan 2002

Fucharoen Supan, Fucharoen Goonnapa, Sanchaisuriya Kanokwan, Surapot Satja

Abstract excerpt

We report the molecular and hematological characterizations of thalassemia caused by interactions of the hereditary persistence of fetal hemoglobin (HPFH)-6 with beta-thalassemia in 2 Thai patients and the HPFH-6 with Hb E in another Thai patient. Marked hypochromic microcytosis, characteristics of thalassemia intermedia, were obvious in the former 2 cases but the latter had much milder clinical phenotype with...

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PMID: 12373089
DOI: 10.1159/000064707

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