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Article

Coinheritance of the different copy numbers of alpha-globin gene modifies severity of beta-thalassemia/Hb E disease.

Annals of hematology - 1 May 2008

Sripichai Orapan, Munkongdee Thongperm, Kumkhaek Chutima, Svasti Saovaros, Winichagoon Pranee, Fucharoen Suthat

Abstract excerpt

beta-Thalassemia/Hb E patients show a range of clinical severities, from nearly asymptomatic to transfusion-dependent thalassemia major. This study investigated the clinical heterogeneity and hematologic parameters obtained in the large cohort of 925 Thai beta 0-thalassemia/Hb E patients. Coinheritance of alpha-thalassemia with beta 0-thalassemia/Hb E produces a milder clinical phenotype in contrast to an...

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PMID: 18026953
DOI: 10.1007/s00277-007-0407-2

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Source receipt: pubmed, retrieved 7 Sept 2026.

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