Article
Phenotypic expression of Hb F in common high Hb F determinants in Thailand: roles of α-thalassemia, 5' δ-globin BCL11A binding region and 3' β-globin enhancer.
European journal of haematology - 1 Jan 2014
Prakobkaew Nattaphol, Fucharoen Supan, Fuchareon Goonnapa, Siriratmanawong Nirut
Abstract excerpt
BACKGROUND: Deletions of δ- and β-globin genes are associated with different Hb F levels. To address this, we have examined hematological and molecular characteristics in a large cohort of high Hb F determinants in Thailand. METHODS: A total of 160 unrelated adult subjects with heterozygous trait for high Hb F determinants and another 10 patients with compound heterozygous trait for Hb E were selectively...
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