Article
Molecular, hematological and clinical aspects of thalassemia major and thalassemia intermedia associated with Hb E-beta-thalassemia in Northeast Thailand.
Blood cells, molecules & diseases - 1 Jan 2000
Nuntakarn Lalana, Fucharoen Supan, Fucharoen Goonnapa, Sanchaisuriya Kanokwan, Jetsrisuparb Arunee, Wiangnon Surapon
Abstract excerpt
Hb E-beta-thalassemia is the most common form of beta-thalassemia found in Thailand. The disease exhibits a varied clinical expression ranging from severe transfusion dependence to relatively mild thalassemia intermedia. We evaluated the effects of primary and secondary genetic factors in modulating the hematological and clinical presentation of 148 northeast Thai patients including 103 severe thalassemia major...
Topics
- Hemoglobin E
- Humans
- Mutation
- Polymorphism, Genetic
- Thailand
- beta-Globins
- beta-Thalassemia