Article
A large cohort of β(+)-thalassemia in Thailand: molecular, hematological and diagnostic considerations.
Blood cells, molecules & diseases - 1 Feb 2015
Yamsri Supawadee, Singha Kritsada, Prajantasen Thanet, Taweenan Wachiraporn, Fucharoen Goonnapa, Sanchaisuriya Kanokwan, Fucharoen Supan
Abstract excerpt
We report the molecular and hematological characteristics associated with a large cohort of β(+)-thalassemia in Thailand. Study was done on 21,068 unrelated subjects referred to our center in northeast Thailand for hemoglobinopathies investigation. Among 21,068 subjects, 2637 (12.5%) were found to carry β-thalassemia. Of these 2637 cases, 705 (26.7%) carried β(+)-thalassemia with eight different mutations...
Topics
- Codon
- Cohort Studies
- Female
- Genetic Heterogeneity
- Genetic Testing
- Genotype
- Hemoglobin A2
- Hemoglobin E
- Hemoglobins, Abnormal
- Humans
- Male
- Mutation
- Phenotype
- Promoter Regions, Genetic
- Thailand