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Article

Mitochondrial DNA mutations and oxidative damage in skeletal muscle of patients with chronic uremia.

Journal of biomedical science - 1 Jan 2002

Lim Paik-Seong, Ma Yi-Shing, Cheng Yueh-Mei, Chai Henry, Lee Cheng-Feng, Chen Tzu-Ling, Wei Yau-Huei

Abstract excerpt

Abundant evidence has been gathered to suggest that mitochondrial DNA (mtDNA) sustains many more mutations and greater oxidative damage than does nuclear DNA in human tissues. Uremic patients are subject to a state of enhanced oxidative stress due to excess production of oxidants and a defective antioxidant defense system. This study was conducted to investigate mtDNA mutations and oxidative damage in skeletal...

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Identifiers

PMID: 12372993
DOI: 10.1159/000064728

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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